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Methotrexate is used for treating certain types of cancer, severe psoriasis, or rheumatoid arthritis in certain patients. It may be used alone or with other medicines. Methotrexate is an antimetabolite. It works to treat cancer and psoriasis by blocking an enzyme needed for cell growth. This helps to slow the growth of cancer cells and abnormal skin cells. It reduces symptoms of inflammation (eg, pain, swelling, stiffness) caused by rheumatoid arthritis.
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